Off-label treatments were not consistently better or worse than approved drug treatments in randomized trials

Off-label drug use is highly prevalent, but controversial and often discouraged assuming generally inferior medical effects associated with off-label use.

Source: Journal of Clinical Epidemiology - November 13, 2017 Category: Epidemiology Authors: Aviv Ladanie, John P.A. Ioannidis, Randall S. Stafford, Hannah Ewald, Heiner C. Bucher, Lars G. Hemkens Source Type: research