Startup aims to disrupt asthma, COPD space with digital inhaler

Formed just two years ago, pharma startup Pneuma Respiratory is developing a digital inhaler that it touts as the first of its kind. The company is looking to bring its technology to the more than 40 million people who suffer from asthma or chronic obstructive pulmonary disease in the U.S. They’re stepping into a highly competitive market, largely dominated by companies like GlaxoSmithKline (NYSE:GSK) and Merck (NYSE:MRK). Get the full story at our sister site, Drug Delivery Business News. The post Startup aims to disrupt asthma, COPD space with digital inhaler appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Drug-Device Combinations mHealth (Mobile Health) Pharma Pharmaceuticals Respiratory GlaxoSmithKline plc Merck Pfizer pneumarespiratory Source Type: news

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(European Lung Foundation) The European Respiratory Society International Congress will take place at the Paris Expo Porte de Versailles from September 15 to 19, 2018.The Congress will be attended by the world's leading respiratory experts who will present cutting-edge research in a large and varied scientific program. Over 4,000 abstracts will cover a diverse range of disease areas and specialisms, including lung cancer, asthma and COPD, children's lung health, personalized medicine, e-cigarettes, AI and risk factors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 18 July 2018Source: SynergyAuthor(s): Lisa Joy Juergens, Izabella Tuleta, Meinolf Stoeber, Kurt Racké, Uwe R. JuergensAbstractBackgroundAirway mucus hypersecretion is the typical feature of COPD and asthma. Hypersecretion is caused by reactive oxygen species (ROS) and links the COPD-bronchitis phenotype to frequent exacerbations. Since the monoterpene 1,8-cineole is known for its secretolytic activity, we studied the antioxidant activity of 1,8-cineole.MethodsUsing a culture model of fetal calf serum (FCS)-stimulated human monocytes, we determined the effects of 1,8-cineole, at the...
Source: Synergy - Category: Molecular Biology Source Type: research
AbstractPurposeComorbidities associated with chronic obstructive pulmonary disease (COPD) affect quality of life and increase mortality. Asthma –COPD overlap (ACO) may express a different profile of comorbidities compared to COPD alone. It is unclear how recent changes in GOLD recommendations affect the profile of comorbidities in COPD and ACO.MethodsEight hundred and thirty-four patients with COPD were recruited from 67 Hungarian secondary care outpatient clinics, 469 of them had ACO. Comorbidities were defined by respiratory specialists based on medical history, patient report, and medications. COPD grades were def...
Source: Lung - Category: Respiratory Medicine Source Type: research
Publication date: Available online 11 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Su May Liew, Norita Hussein, Nik Sherina Hanafi, Hilary Pinnock, Aziz Sheikh, Ee Ming Khoo
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Abstract Air-liquid interface culture enables airway epithelial cells to differentiate into a pseudostratified cell layer, consisting of ciliated cells, goblet/secretory cells, and basal cells (Ghio et al., Part Fibre Toxicol 10:25, 2013). This technique is critically important for in vitro studies of lung diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, since differentiated airway epithelial cells are more representative of the in vivo lung environment than non-differentiated cells (Derichs et al., FASEB J 25:2325-2332, 2011; Hackett et al., Am J Respir Cell Mol Biol 45:1090-11...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Methods Mol Biol Source Type: research
ConclusionThe majority of patients in this study could not use their MDI appropriately. Thus, patients should be educated regarding correct MDI technique upon dispensing of inhaler medications. Training and educational intervention programs may contribute to improved MDI technique among patients.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
Publication date: July 2018Source: The Lancet Respiratory Medicine, Volume 6, Issue 7Author(s): Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J AllenSummaryBackgroundLifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification of these trajectories, their determinants, and ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: July 2018Source: The Lancet Respiratory Medicine, Volume 6, Issue 7Author(s): Danielle C M Belgrave, Raquel Granell, Steve W Turner, John A Curtin, Iain E Buchan, Peter N Le Souëf, Angela Simpson, A John Henderson, Adnan CustovicSummaryBackgroundMaximal lung function in early adulthood is an important determinant of mortality and COPD. We investigated whether distinct trajectories of lung function are present during childhood and whether these extend to adulthood and infancy.MethodsTo ascertain trajectories of FEV1, we studied two population-based birth cohorts (MAAS and ALSPAC) with repeat spirometr...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
This report presents the primary analysis. The PASS study is registered in the European Genome-phenome Archive (EGA). The PASS study is complete whereas the PASIC study is ongoing.FindingsBetween November, 2008, and September, 2011, 499 children were enrolled to the discovery cohort. Between October, 2011, and December, 2012, 81 children were enrolled to the paediatric validation cohort, and from February, 2010, to June, 2015, 78 adults were enrolled to the adult validation cohort. Adrenal suppression was present in 35 (7%) children in the discovery cohort and six (7%) children and 17 (22%) adults in the validation cohorts...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 23 February 2018Source: The Lancet Respiratory MedicineAuthor(s): James D Chalmers, Sanjay H ChotirmallSummaryEuropean Respiratory Society guidelines for the management of adult bronchiectasis highlight the paucity of treatment options available for patients with this disorder. No treatments have been licensed by regulatory agencies worldwide, and most therapies used in clinical practice are based on very little evidence. Development of new treatments is needed urgently. We did a systematic review of scientific literature and clinical trial registries to identify agents in early-to-late c...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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