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Asthma UK claims THIS is to blame for nearly 1000 preventable UK deaths

ASTHMA UK urged patients to visit their GP every year for annual check-ups, after 1000 deaths by the condition could have been prevented in 2016, it claimed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. D...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Perciaccante A, Charlier P, Negri C, Coralli A, Appenzeller O, Bianucci R Abstract A1AT deficiency- a genetically inherited autosomal codominant disease with more than 120 identified alleles- was first identified by Laurell and Eriksson in 1963. The most common hereditary disorder in adults, A1AT causes an increased risk of developing pulmonary emphysema and liver disease. In A1AT patients, lung disease generally presents at a younger age than "usual" chronic obstructive pulmonary disease (COPD) and it may be misdiagnosed as asthma. Because A1AT deficiency patients can show the same clinical feat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study presents a rational design approach to discovery synthetic peptide vaccine candidates from endogenous proteins for chronic non-infectious diseases immunological therapeutics. The approach described the screening of key antigenic amino acid residues of the interleukine-13, which is up-regulated expression in asthma, followed by the development of immunological helper epitope peptides via an integrative computational and experimental method. Notably, this totally synthetic peptide vaccine was capable of stimulating humoral immune responses much stronger than those of parental antigenic peptides by enhancing the ef...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
SATURDAY, Feb. 24, 2018 -- Your children may already be looking forward to summer camp. But when it comes to kids with asthma or allergies, parents need to take extra steps in planning their outdoor experience. " Kids with allergies and asthma need...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Authors: Hanefeld C, Haschemi A, Lampert T, Trampisch HJ, Mügge A, Miebach J, Kloppe C, Klaaßen-Mielke R Abstract BACKGROUND: Persons of lower socio-economic status are at higher risk of disease, especially with respect to severe and chronic illnesses. To date, there have not been any studies with large case numbers regarding acute medical emergencies in this population. METHODS: In a retrospective study, data were obtained on all cases treated by emergency physicians in Bochum, Germany, in 2014/2015, including the diagnoses that were made by the emergency physicians. There were a total of 16 767 cas...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Publication date: Available online 23 February 2018 Source:Trends in Pharmacological Sciences Author(s): Eduardo N. Chini, Claudia C.S. Chini, Jair Machado Espindola Netto, Guilherme C. de Oliveira, Wim van Schooten Recent reports indicate that intracellular NAD levels decline in tissues during chronological aging, and that therapies aimed at increasing cellular NAD levels could have beneficial effects in many age-related diseases. The protein CD38 (cluster of differentiation 38) is a multifunctional enzyme that degrades NAD and modulates cellular NAD homeostasis. At the physiological level, CD38 has been implicated in th...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
This study aimed to determine its effect on telomere length and lung function in school‐aged children born preterm with BPD. MethodsWe examined 29 children with BPD, born preterm in Stockholm county 1998‐99, along with 28 children with allergic asthma born at term matched for age and gender. At 10 years of age, we measured relative telomere length (RTL) in blood by quantitative polymerase chain reaction, lung function by spirometry and inflammation by fractional exhaled nitric oxide and blood cytokines. ResultsRTL was not different in preterm born with BPD compared to term born children with asthma. The gender effect w...
Source: Acta Paediatrica - Category: Pediatrics Authors: Tags: Regular Article Source Type: research
This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine> Toxicology of Nanomaterials The Rosetta Stone ia a stone with writing carved into it. It was found in Egypt in 1799, and was crucial in understanding the meaning of the Ancient Egyptian writing system called hieroglyphics. In fact, it had three pieces of writing on it that said the same thing in three diferent languages. One was in an Ancient Egyptian script called demotic, the other two languages were hieroglyphics and Ancient Greek. The interpretation of the data o experimental studies on the toxicity of engineered nanomaterials ar...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - Category: Nanotechnology Authors: Tags: OVERVIEW Source Type: research
Authors: Schaller A, Metz-Favre C, Guenard-Bilbaut L, De Blay F Abstract The Fernand Widal syndrome is a set of associations between asthma, nasal polyposis and aspirin sensitivity. Selective cyclo-oxygenase 2 (COX 2) inhibitors are recognized as being a therapeutic alternative in cases needing analgesic or anti-inflammatory treatment. In a retrospective study, we have compiled data concerning oral provocation tests (OPT) undertaken with celecoxib, one of most the selective COX 2 inhibitors, in eight patients with the Fernand Widal syndrome. They were compared with twenty-seven control patients with sensi...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Camille Ribeyre, Federico Carlini, C éline René, François Jordier, Christophe Picard, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Nicolas Molinari, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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