Dexamethasone/Povidone-Iodine Effective for Conjunctivitis Dexamethasone/Povidone-Iodine Effective for Conjunctivitis
The experimental combination led to clinical resolution and viral eradication in a randomized, controlled phase 2 trial.Medscape Medical News
Human adenoviruses (HAdVs) consist of seven different species (A to G) subdivided into 67 HAdV types [1,2]. HAdV typing is performed by PCR amplification and sequencing of a hypervariable region of the hexon gene, coding for one of three HAdV capsid proteins. HAdV can cause a wide range of diseases, namely febrile respiratory tract infections, conjunctivitis, diarrhoea and more rarely haemorrhagic cystitis and meningitis. Recent studies identified HAdV among 6% to 20% of hospitalized or emergency room admitted children [3 –6] presenting with lower respiratory tract infections and 10% and 23% of children admitted with...
A 50-year-old woman presented with chronic foreign body sensation in both eyes. She admitted to more than 25 years of heavy mascara use on her lashes with inadequate removal. Eversion of the upper lids revealed multiple darkly pigmented subconjunctival concretions, some eroding through the conjunctival surface (Fig 1A). This was associated with a patchy follicular conjunctivitis and punctate corneal erosions. Histopathological examination of a conjunctival biopsy revealed a chronic inflammatory infiltrate with pigmented macrophages, in keeping with foreign body deposition (Fig 1B).
International Journal of Immunogenetics, EarlyView.
Kawasaki disease (KD) is an acute self-limiting inflammatory disease associated with vasculities, affecting predominantly medium sized vessels and encountered these cases infrequently in clinical practice. The most concerning complication is coronary artery aneurysm (CAA) leading to myocardial infarction or sudden death. Fever is the essential feature. Kawasaki disease is invariably associated with an inflammatory process with elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count. Early recognition and treatment with IVIG (Intravenous venous immunoglobulin), and Aspirin showed h...
Veterinary Ophthalmology, EarlyView.
The mechanical properties of a soft contact lens are of crucial importance to the design and functionality of the lens. To be fit for purpose a lens must be both comfortable and robust; the lens must be rigid enough to allow insertion into the eye, yet flexible enough to allow comfortable on-eye movement. The ability of the lens to revert to its original shape, when placed onto the eye, is critical to its clinical performance. Should the lens be too stiff, however, serious clinical issues, such as superior epithelial arcuate lesions (SEAL), contact lens papillary conjunctivitis (CLPC) and mucin balls are known to develop [1,2].
Abstract Sulfur mustard (SM) is an highly toxic and vesicant chemical weapon that was used in various military conflicts several times in the history. The severity of ocular, dermal, and pulmonary symptoms that may appear following a characteristic asymptomatic period are depending on the SM concentration and exposure duration. The aim of this study is to present the clinical features and share the intensive care unit (ICU) experiences for the medical management of mustard gas victims. Thirteen Free Syrian Army soldiers near Al-Bab region of North Syria were reportedly exposed to oily blackish smoke with garlic sm...
Allergic rhinitis with or without conjunctivitis (AR/C) is common, necessitating evaluation of SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet efficacy in various subgroups.
CONCLUSION: Treatment with 12 SQ-HDM consistently improved symptoms and was well tolerated in relevant subgroups of subjects with HDM AR/C. Local application site reactions to 12 SQ-HDM were typically mild-to-moderate and transient. PMID: 29656145 [PubMed - as supplied by publisher]
Condition: Allergic Conjunctivitis Interventions: Drug: Reproxalap Ophthalmic Solution (0.25%); Drug: Reproxalap Ophthalmic Solution (0.5%); Drug: Vehicle Ophthalmic Solution Sponsor: Aldeyra Therapeutics, Inc. Recruiting