Mycobacterium avium Complex in a Lung Transplant Recipient Mycobacterium avium Complex in a Lung Transplant Recipient
This case highlights the need to be aware that infectious complications following lung transplant can occur at any time in the setting of immunosuppression, even many years post-transplant.Journal of Medical Case Reports
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female, post lung transplant, with cystic fibrosis (CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9.2 μg/mL. Serum half-life was found to be slightly shorter than previously reported in normal subjects, (2.3 hr. v...
PMID: 29153791 [PubMed - in process]
THIS MANUSCRIPT REPORTS a case of a Takotsubo cardiomyopathy (TTC) during a double-lung transplant for a patient with terminal end-stage respiratory failure. The authors focused on the team management and the medical approach to this clinical challenge.
Despite the development of solid phase Luminex-based assays using human leukocyte antigen (HLA)-coated microbeads, there is significant center variability in the identification of HLA antibodies in lung transplantation. Some institutions screen for the presence of any antibodies and then use single antigen beads (SAB) to determine antibody identity if the pre-screen is positive (the pre-screen method).1 Other centers do not pre-screen, using SAB only.2 SAB, however, are significantly more sensitive than pre-screening.
The human microbiome includes a range of micro-organisms that live on or in the different organs of the human body.1 Each body compartment has a unique microbiome, with distinct sets of species that are involved in regulating the healthy functions of that organ system. The microbiome comprises bacteria, fungi, viruses (including bacteriophages) and archaea which appear to be variable between systems. As we have begun to understand, the micro-organisms contained within each system, are essential in the function and maintenance of a healthy state.
Conclusions: PR in patients with end-stage lung disease awaiting lung transplantation on nocturnal NIV is feasible and is associated with improvements of exercise capacity and quality of life. Furthermore, despite more advanced lung disease, patients treated with NIV have an increased benefit of PR compared to patients without NIV while awaiting lung transplantation.Respiration
ABSTRACT Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the tr...