As Men's Weight Rises, Sperm Health May Fall

But shedding pounds may bring them back to normal, researcher says Source: HealthDay Related MedlinePlus Pages: Assisted Reproductive Technology, Male Infertility, Obesity
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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Publication date: Available online 15 May 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Hanna Hürter, Shane Vontelin van Breda, Lenka Vokalova, Marlene Brandl, Marc Baumann, Irene Hösli, Evelin Annegret Huhn, Christian De Geyter, Simona W. Rossi, Olav LapaireAbstractAlthough an increased risk of pre-eclampsia in pregnancies conceived after infertility treatment has been reported, it remains unknown whether preconceptional minimalisation of known risk factors would help in preventing pre-eclamsia. Obesity and preconceptional blood pressure are discussed as major risks for...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Obesity surgery has triggered great enthusiasm as an adjunctive treatment of infertility in women suffering from obesity, polycystic ovarian syndrome and irregular menstrual patterns (1). However, when it comes to male fertility issues, surgical outcomes interpretation is more complex. On one hand, male obesity has been associated with worse quality of semen (2) and weight loss has been shown to improve it (3). On the other hand, whilst one can expect that obesity surgery leads to increased testosterone levels and improved reproductive function, evidence in the field is sparse and inconsistent.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
ConclusionThis study confirms a link between obesity, increasing intestinal permeability and endotoxin exposure, and oxidative mediated sperm DNA damage. This warrants further investigation to fully understand the effect of metabolic endotoxemia on male reproductive function which could result in the new therapies to improve male fertility potential.
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research
Authors: Kurek Eken M, Sahin Ersoy G, Yayla Abide C, Sanverdi İ, Devranoglu B, Kutlu T, Çevik Ö Abstract Polycystic ovary syndrome (PCOS) is a metabolic disorder associated with obesity and energy metabolic system disturbances in adipose tissue. Neuregulin 4 (NRG4), which is secreted by adipose tissue, regulates energy metabolism. In the present study, we aimed to evaluate the association between serum NRG4 levels in obese and normal weight PCOS patients. This cross-sectional study was conducted at a tertiary hospital in Turkey from April to August 2017. We included 148 women who were divided into four...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
AbstractPurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women i...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionsWe recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population.Implications for Cancer SurvivorsThe existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Conclusions Two, Not Mutually Exclusive, Hypotheses We have reviewed and organized the literature with the intent of showing the existing parallels between excessive fat accumulation and the aging process. We have categorized these reports following what have been proposed to be the nine hallmarks of aging (21) (Figure 1). Based on the evidence, two distinct hypotheses can be proposed. One is that the cellular responses provoked by an excess of nutrients cause obesity, and that obesity is responsible for accelerating the pace of aging. Supporting this hypothesis are the observations that knocking out the fat-specific ins...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Xiao Wang and Haja N. Kadarmideen* Quantitative Genomics, Bioinformatics and Computational Biology Group, Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research. Testis is the main organ for reproduction and boar taint in pigs; however, there have been no studies to-date on adult pig testis epigenome. The main objective of this study was to establish a genome-wide DNA methylation map of pig t...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 25 April 2019Source: Life SciencesAuthor(s): Yan Li, Changye Chen, Yan Ma, Jiao Xiao, Guifang Luo, Yukun Li, Daichao WuAbstractPolycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis (HPOA) function disorders. This syndrome results in hyperandrogenemia (HA), hyperinsulinemia/insulin resistance (IR), ...
Source: Life Sciences - Category: Biology Source Type: research
Hongmei Zhu, Sha Nan, Chuanguang Suo, Qiulin Zhang, Manli Hu, Rong Chen, Juan Wan, Meng Li, Jianguo Chen and Mingxing Ding* College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Hypothalamic-pituitary-ovary (HPO) axis is a dominant system controlling ovulation during puberty. Electro-acupuncture (EA) has been widely used to cure the reproductive diseases associated with endocrinological disorders. However, whether EA treatment affects HPO axis activity of physiological animals and induces alterations on the hormones in the HPO axis was also unclear. Here, we performed the EA stimuli on bil...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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