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Could hormone therapy for menopause make a comeback?

New research suggests the hormone therapy won't increase risk of early death
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Research published inMenopause reports that women who stop hormone therapy after menopause are at higher risk of cardiac and stroke death.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
by Germ án D. Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K. Magnusson, Peter M. Nilsson, Nancy L. Pedersen, Alicja Wolk, Karin Leander BackgroundRecent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
(The North American Menopause Society (NAMS)) Hormone therapy (HT) continues to be a hotly debated topic. The benefits of estrogen to the heart, however, appear to be universally accepted. A new study demonstrates that the risk of cardiac and stroke death actually increases in the first year after discontinuation of HT. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
A better understanding of menopausal hormone therapy will help primary care providers adequately counsel and treat women suffering from vasomotor symptoms.Journal for Nurse Practitioners
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nursing Journal Article Source Type: news
The worlds of observational, clinical, and basic science collided in 2002 with the publication of results of the Women’s Health Initiative (WHI), a large-scale, prospective, blinded, randomized-controlled trial designed to provide evidence regarding use of hormone treatment to prevent cardiovascular disease in menopausal women. The results of the WHI dramatically changed clinical practice, negatively impacted funding for hormone research, and left scientists to unravel the "why" of the results. Now over a decade and a half since the initial publication of the WHI results, basic and clinical scientists often...
Source: AJP: Heart and Circulatory Physiology - Category: Cardiology Authors: Tags: REVIEW Source Type: research
CONCLUSIONS: As the global burden associated with respiratory conditions continues to rise, the need to understand the associations between menopause and respiratory health is essential to identify potentially modifiable risk factors for respiratory disease in adult women. More studies are needed to clarify the impact of menopause on obstructive lung disease. PMID: 29106307 [PubMed - as supplied by publisher]
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying molecular mechanisms remain poorly understood. The inflammatory cytokine TNFα causes EC apoptosis while dysregulating the Notch pathway, a major contributor to EC survival. We have previously reported that 17β-estradiol (E2) treatment activates Notch signaling in ECs. Here, we sought to assess whether in TNFα-induced inflammation Notch is involved in E2-media...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
Introducing hormone treatment for women in early stages of menopause might help decrease their risk of dementia or Alzheimer's disease. For women, a drop in hormones during midlife may have some influence on developing dementia or Alzheimer's disease. Also, general brain volume gradually declines with advancing age, but the decline is faster in people who [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
This report is a record of the proceedings of that symposium. The maxim about HT for the past 15 years since the publication of the initial results of the Women's Health Initiative (WHI) has been to prescribe the “lowest dose for the shortest period of time.” With new clinical trials, observational data, and further analysis of the WHI and the cumulative 13 years’ follow-up, it was time to hold a conversation about the state of the evidence and recommendations for HT dose, route, and duration of use. The symposium brought together experts in the field of HT to speak on these topics, organized by session...
Source: Menopause - Category: OBGYN Tags: NAMS Translational Science Symposium Report Source Type: research
Conclusion: In this study, the adverse LV structure and function observed among women with SM compared with NM were explained by their unfavorable presurgical CVDRF profiles, suggesting that premenopausal CVDRF rather than gynecologic surgery predispose SM women to elevated future cardiovascular disease risk.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
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