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Airway Mucin Concentrations May Help Predict Chronic Bronchitis

Mean total mucin concentrations up in smokers with severe COPD, those with respiratory exacerbations
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Infections, Internal Medicine, Pathology, Pulmonology, Journal, Source Type: news

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Abstract Airways diseases, especially chronic obstructive pulmonary disease (COPD) and asthma, are common causes of morbidity and mortality worldwide. There is an ongoing unmet need for novel and effective therapies. There is an established pathophysiological link and phenotypic similarity between the chronic bronchitis phenotype of COPD and cystic fibrosis (CF). New evidence suggests that CFTR dysfunction may play a role in other common airways diseases such as COPD, non-atopic asthma and non-CF bronchiectasis. Newly approved and investigational drugs that target both mutant and wildtype CFTR channels have provid...
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Opin Pharmacol Source Type: research
CONCLUSION: Octogenarian patients with COPD have differential characteristics which could imply the need for different therapeutic approaches. Prognostic indexes are useful for predicting mortality in this population. PMID: 29096969 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Abstract PROBLEM/CONDITION: Many rural residents work in the field of agriculture; however, employment in nonagricultural jobs also is common. Because previous studies in rural communities often have focused on agricultural workers, much less is known about the occupational exposures in other types of jobs in rural settings. Characterizing airborne occupational exposures that can contribute to respiratory diseases is important so that differences between rural and urban working populations can be assessed. REPORTING PERIOD: 1994-2011. DESCRIPTION OF SYSTEM: This investigation used data from the baseline ...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
Abstract Although chronic cough in adults (cough lasting longer than eight weeks) can be caused by many etiologies, four conditions account for most cases: upper airway cough syndrome, gastroesophageal reflux disease/laryngopharyngeal reflux disease, asthma, and nonasthmatic eosinophilic bronchitis. Patients should be evaluated clinically (with spirometry, if indicated), and empiric treatment should be initiated. Other potential causes include angiotensin-converting enzyme inhibitor use, environmental triggers, tobacco use, chronic obstructive pulmonary disease, and obstructive sleep apnea. Chest radiography can r...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Nature Reviews Drug Discovery 16, 752 (2017). doi:10.1038/nrd.2017.203 Author: Sarah Crunkhorn Currently available therapies for obstructive airway diseases, such as asthma, bronchitis and chronic obstructive pulmonary diseases (COPD), may be limited by poor disease control, adverse effects or a lack of efficacy. Writing in Science Translational Medicine, Matthey et al. now demonstrate that pharmacological
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research
Conclusions: Lag 0–2 OPDTT was associated with ED visits for multiple cardiorespiratory outcomes, providing support for the utility of OPDTT as a measure of fine particle toxicity. https://doi.org/10.1289/EHP1545 Received: 23 December 2016 Revised: 4 August 2017 Accepted: 12 August 2017 Published: 26 October 2017 Please address correspondence to J.Y. Abrams, Centers for Disease Control and Prevention, NCEZID/DHCPP, 1600 Clifton Rd. NE, CDC Mailstop A30, Atlanta, GA 30333 USA. Telephone: (404) 639-5121. Email: jabrams@cdc.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1545). The authors ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: Prescription pattern was mainly in accordance with standard guidelines with some knowledge and technical gaps in prescription writing methodology.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
CONCLUSION: While the quality of evidence was low, the published literature since 2006 suggests that the CHEST Organization's 2006 Cough Guidelines and management algorithms for acute, subacute, and chronic cough in adults appeared useful in diagnosing and treating patients with cough around the globe. These same algorithms have been updated to reflect the advances in cough management as of 2017. PMID: 29080708 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
BRONCHITIS is usually caused by flu and goes within weeks, however if symptoms linger it could be chronic bronchitis - a key cause of deadly lung condition, COPD, among smokers.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewVaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig ...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
More News: Bronchitis | Chronic Obstructive Pulmonary | Geriatrics | Internal Medicine | Pathology | Respiratory Medicine | Smokers