Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis

Necroptosis is a programmed form of inflammatory cell death involved in various pathologies, such as viral infections. In two new papers published in The EMBO Journal and EMBO Reports, Z-DNA binding protein 1 (ZBP1) is now shown to sense RNAs during viral infection or after caspase inhibition and activate necroptosis. This may suggest that Z-RNAs are molecular patterns for activation of necroptosis.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Autophagy & Cell Death, Immunology News [amp ] Views Source Type: research