A forceful connection: mechanoregulation of oncogenic YAP

The Yes-associated protein (YAP) is an important transcriptional co-activator that mediates the cellular response to mechanical and cytoskeletal cues. In two recent papers published in The EMBO Journal, Dae-Sik Lim and colleagues show how YAP activity affects cancer formation and metastasis via a crosstalk with myocardin-related transcription factors (MRTFs; Kim et al, 2017) and SKP2-dependent cell cycle progression (Jang et al, 2017).
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Signal Transduction, Transcription News [amp ] Views Source Type: research