MRD Level in NPM1 Mutated and RUNX1-RUNX1T1 Positive AML Predicts RFS and Defines Indications for ASCT

NPM1 mutation and leukemia-specific fusion transcript RUNX1-RUNX1T1 are the predictors of favorable prognosis (DFS and OS). Nevertheless, a substantial proportion of this patients show disease relapses. It is necessary to identify negative prognostic factors for pts with NPM1mut and RUNX1-RUNX1T1 and evaluate if ASCT could overcome them.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Larisa Girshova, Irina Budaeva, Sergey Kuzin, Ekaterina Ovsiannikova, Konstantin Bogdanov, Tatjana Nikulina, Julia Mirolyubova, Dmitriy Motorin, Andrey Zaritskey Source Type: research