hnRNPK as a Driver of Lymphomagenesis

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a multi-functional ssDNA and RNA binding protein that regulates a multitude of cellular programs involved in tumorigenesis. Accumulating biochemical data suggest hnRNP K may have oncogenic functions through its transcriptional and translational activities. While clinical data from solid tumors suggest a potential role for hnRNP K in some tumor types, its role in lymphoid malignancies has not been studied.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Prerna Malaney, Marisa Hornbaker, Miguel Gallardo, Xiaorui Zhang, Mark McArthur, Carlos Bueso-Ramos, Ken Young, Juaquin Martinez-Lopez, Sean Post Source Type: research