Why a diabetes drug could help in Parkinson's disease

Using cell cultures, German researchers show how the drug may regulate the energy balance in damaged body cells.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In the materials noted here, a Buck Institute researcher puts forward a view of just one side of the science of advanced glycation end-products (AGEs) and their role in degenerative aging. AGEs are sugary metabolic byproducts of many different varieties, both present in the diet and generated in the body. In the view of AGEs and aging expounded here, near all of the many types of AGE are important, most are transient and levels will vary in response to day to day circumstances, dietary intake of AGEs probably has a significant negative influence on long-term health, and AGEs present in tissues disrupt metabolism by hammeri...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
When Nichelle Obar learned she was pregnant with her second child last year, she never expected that her pregnancy, or her baby, would make history. But when the 40-year-old food-and-beverage coordinator from Hawaii and her fiancé Christopher Constantino went to their 18-week ultrasound, they learned something was wrong. The heart was larger than it should have been, and there was evidence that fluid was starting to build up around the organ as well. Both were signs that the fetus was working extra hard to pump blood to its fast-growing body and that its heart was starting to fail. Obar’s doctor knew what coul...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized medicine Source Type: news
Neurogenic postural hypotension is a debilitating condition in patients with Parkinson's disease, multiple system atrophy (MSA), autoimmune autonomic ganglionopathy, and advanced diabetic neuropathy (Palma and Kaufmann, 2017). Pathology for this condition are mostly peripheral (periarterial nerves innervating alpha 1B receptors on the vessel wall), and in MSA, spinal intermediolateral nucleus and medullary A1,2/C1,2 neurons are the responsible sites. In pure autonomic failure (lesion overlaps that of Parkinson's disease), cingulate and medial frontal pathology is contributing to postural hypotension (Hirano et al, 2009).
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Editorial Source Type: research
(Natural News) Only in America is every single disease and disorder diagnosed by medical doctors as genetic, meaning inherited from your parents’ and grandparents’ genes, even though nearly all of the most popular chronic illnesses, like cancer, diabetes, heart disease, high blood pressure, high cholesterol, strokes, arthritis, osteoporosis, Alzheimer’s, and Parkinson’s barely existed just one...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
To investigate the effect of diabetes mellitus (DM) on the clinicoradiological features in patients with Parkinson's disease (PD).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Abstract Spices are not only just herbs used in culinary for improving the taste of dishes. They are also sources of a numerous bioactive compounds significantly beneficial for health. They have been used since ancient times because of their antimicrobial, anti-inflammatory and carminative properties. Several scientific studies have suggested their protective role against chronic diseases. In fact, their active compounds may help in arthritis, neurodegenerative disorders (Alzheimer's, Parkinson, Huntington's disease, amyotrophic lateral sclerosis, etc.), diabetes, sore muscles, gastrointestinal problems and many m...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
I have posted a few notes about predictive diagnostic algorithms (see:An Algorithm Using Medical Record Data Predicts Risk for Parkinson's Disease;Should the Work Product of"Non-Explainable" Medical Algorithms Be Ignored) and disease risk scores (see:Genetic Risk Scores: Ready for Inclusion in the Medical Record?). Using AI techniques, researchers at Massachusetts General are developing a web site that will display a risk score for five common diseases after consumers upload their DNA to the site (see:Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA). The algorithm takes into account mill...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Source Type: blogs
CONCLUSIONS: Cardiac involvement in m.3243A>G carriers has been only rarely systematically studied, which is perhaps why the incidence of cardiac diseases in MELAS is lower than would be expected. Myocardial abnormalities are much more frequent than arrhythmias or conduction defects. All symptomatic and asymptomatic m.3243A>G carriers should be systematically investigated for cardiac disease. PMID: 30128910 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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