Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases.

Conclusions: Monotypic IgG4+ proliferations include lymphomas, plasmacytic neoplasms, and a previously uncharacterized group of proliferations not meeting criteria for conventional hematolymphoid neoplasia. Distinct features included prominent Mott cells and/or monotypic plasma cells within follicles. The proliferations were infrequently associated with IgG4-related disease (IgG4-RD). Our findings raise questions regarding the relationship between clonal IgG4+ proliferations, reactive/inflammatory processes, and IgG4-RD.
PMID: 28821195 [PubMed - in process]

Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Bledsoe JR, Wallace ZS, Deshpande V, Richter JR, Klapman J, Cowan A, Stone JH, Ferry JA Tags: Am J Clin Pathol Source Type: research