An HIV-negative Same-sex Male Couple Both Infected With Hepatitis C Virus.

An HIV-negative Same-sex Male Couple Both Infected With Hepatitis C Virus. Acta Derm Venereol. 2017 Aug 10;: Authors: Achterbergh RCA, Bruisten SM, V D Laar TJW, van der Weijden CP, Scholing M, Cornelissen M, de Vries HJC PMID: 28795764 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Abstract The cost-effectiveness of hepatitis C virus (HCV) screening and treatment was examined in low-income, primarily Hispanic baby boomers born 1945-1965 using a Markov model of the natural history of HCV. The model was parameterized using costs and diagnostic data from 2008-2016 and from literature on disease progression and effectiveness of screening and treatment using direct acting anti-viral (DAA) therapy. The incremental cost-effectiveness ratio (ICER) was computed from the perspective of Medicare as payer, calculated over 20 years, and discounted at 3% per year. In the base case, HCV screening cost $3,3...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
Conditions:   Hepatitis C;   Chronic Hepatitis c;   Hepatitis C, Chronic Intervention:   Other: EC clinic support - whole of practice interventions delivery through nurse-led model Sponsors:   Macfarlane Burnet Institute for Medical Research and Public Health Ltd;   Burnet Institute;   The Alfred;   St Vincent's Hospital Melbourne;   HepatitisVictoria;   Harm Reduction Australia;   Victoria State Government;   Gilead Sciences;   National Health and Medical Research C ouncil, Australia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 19 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Suresh Gorka, Ghulam M. Gulzar, Ghulam N. Yattoo, Jaswinder S. Sodhi, Gulzar A. Dar, Mushtaq A. Laway, Saurabh Kaushik, Neeraj Dhar, Syed Mushfiq, Riffat A. AzizBackgroundOur data is one of the earliest study from the Indian subcontinent on Velpatasvir/Sofosbuvir (VEL/SOF) combination in chronic hepatitis C (CHC). The primary end point was to evaluate sustained virologic response (SVR) 12 in CHC-infected patients and to determine its effect in patients with hepatitis C virus–related cirrhosis. The sec...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Conclusions: These findings demonstrated that TILs are potential survival predictors in HCC and different kinds of TILs are observed according to the virus type. Therefore, further investigations are warranted to elucidate the role of TILs in HCC, which may improve immunotherapy outcomes.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Prior hepatitis B virus infection (PBI) may increase the risk of developing hepatocellular carcinoma (HCC), but the impact of PBI on clinical outcomes following treatment for HCC remains unknown. The aim of th...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
ConclusionsThe efficacy of adding bavituximab to sorafenib for the treatment of advanced HCC was inconclusive; however, the combination regimen did not exacerbate toxicities associated with single-agent sorafenib.ClinicalTrials.gov identifierNCT01264705.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
Birth cohort screening for the hepatitis C virus (HCV) has been implemented in the US, but there is little evidence of its cost-effectiveness in England. We aim to evaluate the cost-effectiveness of one-time HCV screening for individuals born between 1950 and 1979 as part of the National Health Service health check in England, a health check for adults aged 40 to 74 years in primary care.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
AbstractPurpose of ReviewReview epidemiology, screening recommendations, management, and treatment of hepatitis C virus and strategies to expand diagnosis and effective linkage to care.Recent FindingsHepatitis C virus (HCV) infections have increased threefold from 2010 to 2016 and close to half of people infected remain unaware of their HCV status. Emergency departments and hospitals are points of care where health care is provided to people who often do not otherwise receive regular primary health care and recommended screening tests. Recent studies in emergency departments have shown that expanded testing can identify ma...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions Despite a limited number of patients, a male predominance and late-onset psoriasis were frequently observed. Although interferon therapy for HCV can exacerbate psoriasis, it is not contraindicated. All conventional treatments and anti-TNFs can be used, provided that there is strict collaboration with hepatologists. PMID: 31418622 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
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