Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy

Conclusion: These data show that AATD COPD patients do not experience the same chronic systemic inflammation and exhibit reduced inflammation compared to non-AATD COPD patients. Augmentation therapy may help to improve muscle efflux of TNFalpha and reduce muscle TNFalpha concentration, but showed no effect on IL-6, IL-1beta or CRP.
Source: BMC Pulmonary Medicine - Latest articles - Category: Respiratory Medicine Authors: Source Type: research