Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

It is unclear how DNA sensing by DCs is superior to macrophages. Xu et  al. show that DCs are specialized in sensing mtDNA after CD47 blockade through inhibiting uptaken DNA degradation in their phagosomes while macrophages rapidly degrade DNA.

Source: Immunity - August 8, 2017 Category: Allergy & Immunology Authors: Meng Michelle Xu, Yang Pu, Dali Han, Yaoyao Shi, Xuezhi Cao, Hua Liang, Xiang Chen, Xiao-Dong Li, Liufu Deng, Zhijian J. Chen, Ralph R. Weichselbaum, Yang-Xin Fu Tags: Article Source Type: research