T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node

Dendritic cells (DCs) in the lymph node (LN) T  cell zone are thought to be central to the clearance of apoptotic cells and T cell priming. Baratin et al. identify a population of LN macrophages that act as the sole professional scavengers in this area, suggesting that silent efferocytosis and T cell activation in the LN paracortex involve t wo different cell types—macrophages and DCs, respectively.

Source: Immunity - August 8, 2017 Category: Allergy & Immunology Authors: Myriam Baratin, L éa Simon, Audrey Jorquera, Clément Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc Bajénoff Tags: Article Source Type: research