Fibromatosis-like Spindle Cell Carcinoma of the Breast Fibromatosis-like Spindle Cell Carcinoma of the Breast
This case describes the clinical and imaging findings of a rare triple negative, fibromatosis-like metaplastic spindle cell breast carcinoma.Applied Radiology
AbstractSpindle cell lesions of the breast comprise a heterogeneous group of lesions, ranging from reactive and benign processes to aggressive malignant tumours. Despite their rarity, they attract the attention of breast pathologists due to their overlapping morphological features and diagnostic challenges, particularly on core needle biopsy (CNB) specimens. Pathologists should recognise the wide range of differential diagnoses and be familiar with the diverse morphological appearances of these lesions to make an accurate diagnosis and to suggest proper management of the patients. Clinical history, immunohistochemistry, an...
AbstractSome breast carcinomas have a very low likelihood of metastasis to regional lymph nodes and distant sites and may be considered carcinomas of low malignant potential. In this article, we review the clinical, pathologic, immunophenotypic, and molecular features of selected breast carcinomas of low malignant potential including low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, encapsulated papillary carcinoma, solid papillary carcinoma, and tall cell carcinoma with reversed polarity.
CONCLUSIONS: Our study showed that PIK3CA and TERT promoter mutations were common genetic features of FLSCCs. These ﬁndings contribute to our understanding of FLSCCs biology.PMID:33952589 | DOI:10.1136/jclinpath-2020-207071
Int J Clin Exp Pathol. 2021 Mar 1;14(3):355-362. eCollection 2021.ABSTRACTMetaplastic breast carcinoma is a rare invasive breast cancer. Metaplastic breast carcinoma is mainly characterized by an epithelial or mesenchymal cell population mixed with adenocarcinoma. We collected 26 cases of metaplastic breast carcinoma in the First Affiliated Hospital of Bengbu Medical College from 2008 to 2014. Tumor size, tumor grade, vascular invasion, ER/PR status, histologic classification, and HER2/neu status were assessed for all cases and the literature was reviewed. Clinicopathologic characteristics of patients diagnosed with metapl...