CRISPRing the Regulatory Genome, the Challenge Ahead.

CRISPRing the Regulatory Genome, the Challenge Ahead. Trends Genet. 2017 Jul 29;: Authors: Sansbury SE, Sweeney KM, Shalem O Abstract CRISPR saturation mutagenesis has the potential to dissect the functional landscape of noncoding regions, but is highly susceptible to false discovery and misinterpretation. As recently published, Canver et al. have now taken the first steps towards addressing these issues by increasing screening resolution and analyzing the effects of off targets on hit calling. PMID: 28764860 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28764860?dopt=Abstract

Source: Trends in Genetics : TIG - July 29, 2017 Category: Genetics & Stem Cells Authors: Sansbury SE, Sweeney KM, Shalem O Tags: Trends Genet Source Type: research

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