Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione and superoxide ‐dependent manner

ConclusionsWe report DMF as a potent, stimulus‐specific, L‐Glutathione, and ROS‐dependent modulator of NET formation. Our results support the notion that modulation of NET formation contributes to the beneficial effects of fumaric acid esters in a variety of inflammatory conditions.This article is protected by copyright. All rights reserved.

Source: British Journal of Dermatology - July 22, 2017 Category: Dermatology Authors: J. H.O. Hoffmann, K. Schaekel, D. Hartl, A. H. Enk, E. N. Hadaschik Tags: Original Article Source Type: research