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FDA OKs Guselkumab for Plaque Psoriasis

(MedPage Today) -- First selective IL-23 blocker to reach market
Source: MedPage Today Public Health - Category: American Health Source Type: news

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Authors: Paton DM Abstract Guselkumab is an antibody designed to bind to the p19 subunit of interleukin-23 (IL-23). Detailed studies of affected skin in patients with psoriasis demonstrated that guselkumab induced significant changes in the cellular, cytokine and gene expression profiles of psoriatic lesions accompanied by significant changes in clinical measures of disease activity. The significant clinical response in psoriasis was demonstrated in these studies by significant improvement as reflected in the percentage of patients achieving a Physicians Global Assessment score of 0 or 1, and a 90% or 100% improvem...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Immunohistochemical expression HIF1α in chronic plaque psoriasis, an association with angiogenesis and proliferation. J Immunoassay Immunochem. 2018 May 17;:1-14 Authors: Abdou AG, Farag AGA, Hammam M, Taie DM, Abdelaziz RA Abstract Psoriasis is characterized by excessive cell proliferation, angiogenesis, and regions of hypoxia. Hypoxia stimulates production of hypoxia inducible factors (HIFs) such as HIF1α. The aim of the present study is to investigate the possible role of HIF1α in pathogenesis of psoriasis and to correlate its expression with angiogenesis and proliferation in invol...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
DISCUSSION: There was wide variation in patient preference for topical medication vehicles used for treating psoriasis. Several vehicle characteristics were considered important to adherence. Given the marked variation in vehicle preference, topical treatment should be individualized according to patients' preferences. PMID: 29770722 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Abstract Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, ...
Source: The American Journal of Clinical Hypnosis - Category: Complementary Medicine Authors: Tags: Am J Clin Hypn Source Type: research
In June, the FDA will discuss the New Drug Application for Remoxy ER at an Advisory Committee meeting. Remoxy ER is a 12-hour, abuse-deterrent, extended-release oxycodone in a capsule formulation.1 The capsule contains a sticky, thick, high-viscosity formulation to deter unapproved drug administration routes, including injection, smoking or snorting.... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Drug Updates adalimumab NSAIDs Oxycodone plaque psoriasis tildrakizumab-asmn Source Type: research
(University of Pennsylvania School of Medicine) An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation -- a key marker of future risk of major cardiovascular events -- unlike other antibodies that target different aspects of the immune system.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This report demonstrates that sampling and detection of IL-36 γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Imagine you have a friend named Justin. He is a schoolteacher. Honest, hardworking, doesn’t smoke, rarely drinks alcohol, sleeps well, doesn’t take drugs, shows up at work every day. He has also chosen to be vegetarian. Another friend of yours, an auto mechanic named Tommy, eats fast food, loves fried chicken, drinks too much beer on the weekends, likes to drive fast cars, and sometimes gets into legal tangles. He smokes cigarettes, though has limited it to only half-a-pack per day. Late weekends, some weekday nights, sleep cut short to just two or three hours. Tommy is not a vegetarian, but likes his burgers r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
Irfan A. Rather, Vivek K. Bajpai, Yun S. Huh, Young-Kyu Han, Eijaz A. Bhat, Jeongheui Lim, Woon K. Paek, Yong-Ha Park
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study aimed to examine psychopathology and personality in a group of patients affected by psoriasis by means of a self-report measure (Millon Clinical Multiaxial Inventory – MCMI-III) and a performance-based technique (Wartegg Drawing Completion Test [WDCT], CWS). Study results showed a higher rate of passive-aggressiveness and paranoia among psoriatic patients (MCMI-III). When assessing patients through the performance-based technique (WDCT, CWS), a higher rate of global rejection (GR) – linked by previous literature to suicidal ideation – and a lower affective quality of the drawings emerged. We di...
Source: Rorschachiana - Category: Psychiatry & Psychology Source Type: research
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