Current and emerging concepts in atopic dermatitis pathogenesis

Atopic dermatitis is a common skin disorder with a complex, evolving pathogenesis. Research on the pathogenesis has shifted from focusing primarily on generalized immune system abnormalities in T helper 1/T helper 2 (Th1/Th2) activity to more targeted immune and skin barrier abnormalities contributing to the overall phenotype. Specific signaling pathways recently implicated in atopic dermatitis include production of interleukin (IL) 4 and IL-13, which promote immunoglobulin E production, Th17 and Th22 cells, and production of cytokines.

Source: Clinics in Dermatology - July 1, 2017 Category: Dermatology Authors: Marguerite Sullivan, Nanette B. Silverberg Source Type: research