Low Testosterone Lawsuits Transferred to Federal Multidistrict...

All Pending and Future Testosterone Lawsuits Filed in Federal Courts Involving AndroGel, Axiron, Testim, Foresta, AndroDerm and Depo-Testosterone Will be Transferred to the U.S. District Court,...(PRWeb June 18, 2014)Read the full story at http://www.prweb.com/releases/2014/06/prweb11949048.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news

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The fetal hypothalamus-pituitary gonadal (HPG) axis begins to function during mid-gestation but its activity decreases during late pregnancy due to the suppressive effects of placental estrogens. Placental hormones drop immediately after birth, FSH and LH surge at around 1 week and peak between 1 and 3 months of life. The HPG axis is activated in both sexes, but a sexual dimorphism is evident with higher LH values in boys, while FSH prevails in girls. Both gonadotrophins decline in boys by around 6 months of age. In girls, LH declines at the same time as in boys, while FSH persists elevated up to 3 or 4 years of age. As a ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In Reply We thank Lopez and Ghuman for their comments about our study demonstrating significant associations between concussion symptoms and self-reported low testosterone levels or erectile dysfunction (ED) among former professional US-style football players.
Source: JAMA Neurology - Category: Neurology Source Type: research
To the Editor The study by Grashow et al on the association of a history of concussion symptoms with self-reported low testosterone levels and erectile dysfunction (ED) seems to suggest that concussion leads to persistent pituitary damage. The body of research regarding traumatic brain injury (TBI) and pituitary dysfunction, including evidence cited by Grashow et al, supports an association between moderate to severe TBI and hypopituitarism, but to our knowledge, research specifically examining the association between concussion and hypopituitarism is lacking. Although pituitary dysfunction is not uncommon following modera...
Source: JAMA Neurology - Category: Neurology Source Type: research
In this study, we identified two unrelated Japanese patients with clinical diagnoses of BBS associated with compound heterozygousSCLT1 mutation. Patient 1 was a 10-year-old girl, and patient 2 was a 22-year-old man. Both the patients showed severe renal dysfunction in childhood, RP, mild intellectual disability, short stature, and truncal obesity, without oral aberrations and polydactyly. Patient 2 also had hypogonadism. We identified two missense variants inSCLT1, c.[1218G  >  A] and [1631A >  G], in both the patients by next-generation sequencing. Subsequent cDNA analysis revealed that c...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
AbstractTestosterone (T) plays a pivotal role in coordinating a series of psychological, cognitive and physical events that might (or might not) culminate in male sexual activity. In fact, T deficiency is associated, in a statistically significant way, with several sexual dysfunctions including erectile dysfunction (ED), reduction of spontaneous erection and hypoactive sexual desire (HSD). Although these associations are statistically significant, there is debate if they are also clinically meaningful. In addition, sexual dysfunctions are present also in several metabolic conditions ‐ such as type 2 diabetes mellitus and...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: REVIEW ARTICLE Source Type: research
Purpose of review The review presents a clinical algorithm for the evaluation and treatment for adolescents with Klinefelter's syndrome who desire fertility preservation. Recent findings Sperm is present in the ejaculate in around 8% of men with Klinefelter's syndrome. Although most are severely oligospermic/azoospermic, 43–45% of men will have sperm found during a testicular sperm extraction, reaching up to 70% in adolescents. Summary Klinefelter's syndrome (47, XXY) causes hypogonadotophic hypogonadism and severe oligospermia/azoospermia rendering natural conception rare. During puberty, boys often require ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
The relationship between sleep and hypogonadism continues to be elucidated.1 Emerging research suggests that the severity of hypogonadal symptoms may be directly impacted by poor sleep quality.2 Normal sleep architecture can be disrupted in various ways including circadian rhythm disorders, obstructive sleep apnea (OSA), or sleep restriction.3 The present study builds upon prior work by Pastuszak et al to showcase that impaired sleep as identified by shift work sleep disorder (SWSD), may predict the presence of hypogonadal symptoms among male nonstandard shift workers.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
This article validates previous Pastuszak et al in terms of the prevalence of hypogonadism in nonstandard shift works but also further differentiates individuals based on sleep quality.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Condition:   Hypogonadism, Male Interventions:   Other: Testosterone Measurements in healthy volunteers after fasting;   Other: Testosterone Measurements after glucose loading Sponsor:   The Royal Wolverhampton Hospitals NHS Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractKey contentThe World Health Organization (WHO) type 1 anovulatory disorders include hypogonadotrophic hypogonadism, hypothalamic amenorrhoea and hypopituitarism.These conditions are encountered primarily in endocrine, gynaecology and reproductive medicine clinics, and can result in amenorrhoea/oligomenorrhoea, subfertility or pregnancy loss.These conditions are associated with estrogen deficiency and therefore have implications for long ‐term bone and cardiovascular health.There is an apparent lack of clarity on diagnostic criteria (including utility of new biomarkers such as anti ‐müllerian hormone) and m...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEWS Source Type: research
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