Helicobacter suis induces changes in gastric inflammation and acid secretion markers in pigs of different ages

AbstractGastric mRNA expression of markers for acid secretion and inflammation and presence of gastric ulceration was studied in naturallyHelicobacter suis-infected and non-infected 2 –3 months old, 6–8 months old and adult pigs. InH. suis-infected 2 –3 months old pigs, IL-8 and IL-1β transcript levels were upregulated in the pyloric gland zone, indicating an innate immune response. A similar response was demonstrated in the fundic gland zone of adult pigs, potentially due to a shift ofH. suis colonization from the pyloric to the fundic gland zone. A Treg response in combination with decreased expressions of IL-8, IL-17A and IFN- γ was indicated to be present in theH. suis-infected 6 –8 months old pigs, which may have contributed to persistence ofH. suis. InH. suis-infected adult pigs, a Treg response accompanied by a Th17 response was indicated, which may have played a role in the decreased number ofH. suis bacteria in the stomach of this age group. The decreased G-cell mass and upregulated expression of somatostatin indicated decreased acid secretion inH. suis-infected 6 –8 months old pigs. InH. suis-infected adult pigs, upregulation of most markers for gastric acid secretion and increased G-cell mass was detected. Presence of severe hyperkeratosis and erosions in the non-glandular part of the stomach were mainly seen in theH. suis-positive groups. These results show thatH. suis infection affects the expression of markers for acid secretion and inflammation...
Source: Veterinary Research - Category: Veterinary Research Source Type: research