Automated quantitative characterisation of retinal vascular leakage and microaneurysms in ultra-widefield fluorescein angiography

In this report, we describe a novel fully automated software platform, which segments MAs and leakage areas in native and dewarped UWFA images with retinal vascular disease. Comparison of the algorithm with human grader-generated gold standards demonstrated significant strong correlations for MA and leakage areas (intraclass correlation coefficient (ICC)=0.78–0.87 and ICC=0.70–0.86, respectively, p=2.1x10–7 to 3.5x10–10 and p=7.8x10–6 to 1.3x10–9, respectively). These results suggest the algorithm performs similarly to human graders in MA and leakage segmentation and may be of significant utility in clinical and research settings.
Source: British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Innovations Source Type: research

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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Cardiol Res Pract. 2021 Jul 13;2021:2970568. doi: 10.1155/2021/2970568. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the association between the lipid profiles and coronary heart disease (CHD) in nondiabetic patients younger than 65 years of age.METHOD: 424 patients were enrolled in this study from January 2019 to December 2020. All the patients were screened for clinically indicated coronary angiography. They were divided into two groups according to the coronary angiography results: 340 patients with the presence of CHD (at least one coronary artery stenosis ≥50%) were classified as the CHD group, and the rest w...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Source Type: research
Cardiol Res Pract. 2021 Jul 22;2021:1948624. doi: 10.1155/2021/1948624. eCollection 2021.ABSTRACTBACKGROUND: Arrhythmia is one of the causes of death in severe coronary artery disease patients who also suffered from cancer. Our research aims to compare the incidence of arrhythmia between severe coronary artery disease patient with and without new-onset tumor. Methodology. We enrolled 79 patients (December 2019-December 2020) with severe coronary artery disease in this study, and 40 of them were complicated with new-onset tumor. The details of all subjects were thoroughly obtained; the laboratory tests were implemented incl...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: The DCP-PD decreased in the nasal and inferior ETDRS subfields during the ovulatory phase in our study. This may indicate the need to consider the menstrual phase when interpreting DCP-PD parameters by OCTA in healthy women.PMID:34336258 | PMC:PMC8292083 | DOI:10.1155/2021/5514575
Source: Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusion. Our study introduces a new quantitative measurement for NV in PDR, combining structure and flow measurement. The structure area remained after treatment, while its flow density and angio area regressed. We propose this measurement method as a more physiological and possibly more comparable metrics.PMID:34336255 | PMC:PMC8294978 | DOI:10.1155/2021/2942197
Source: Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
CONCLUSION: SNPs rs10757278 and rs2383206 allele dosage could predict CAD severity in the Saudi Arab population.PMID:34336004 | PMC:PMC8292076 | DOI:10.1155/2021/5522539
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
CONCLUSIONS: Statin use was not associated with cardiovascular risk reduction in high-risk persons with normal or near normal coronary arteries. More individualised lipid-lowering therapy may benefit this population.PMID:34334544 | DOI:10.5551/jat.63004
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
Int J Hypertens. 2021 Jul 21;2021:5577957. doi: 10.1155/2021/5577957. eCollection 2021.ABSTRACTBACKGROUND: Systolic interarm differences in blood pressure have been associated with all-cause mortality and cardiovascular disease. We investigated the relationship between interarm systolic blood pressure difference and coronary artery disease.METHODS: We retrospectively analyzed data for patients undergoing coronary angiography and brachial-ankle pulse wave velocity examination during hospitalization from 2013 to 2018. Patients underwent simultaneous upper arm blood pressure measurement. Interarm systolic blood pressure diffe...
Source: International Journal of Hypertension - Category: Cardiology Authors: Source Type: research
J Invasive Cardiol. 2021 Aug;33(8):E678.ABSTRACTIn this case, an air bubble was trapped in the mid right coronary artery and it was difficult to differentiate with calcification or thrombus. A correct diagnosis of "filling defect" is necessary because device selection is different for each case. Intravascular ultrasound is useful for differential diagnosis of calcification, thrombus, or air bubble.PMID:34338661
Source: The Journal of Invasive Cardiology - Category: Cardiology Authors: Source Type: research
J Invasive Cardiol. 2021 Aug;33(8):E676-E677.ABSTRACTSubintimal plaque modification to restore some antegrade flow can promote subsequent lesion recanalization (investment procedure) in cases of failed re-entry into the distal true lumen during chronic total occlusion percutaneous coronary intervention. In this case, we aimed to present a case in which TIMI 0 flow was observed in the LAD after unsuccessful PCI attempt, but was left to recover with the investment procedure and TIMI 3 flow was detected in the control angiogram. In unsuccessful PCI-CTO cases, even in the presence of TIMI 0, flow can improve in the future thro...
Source: The Journal of Invasive Cardiology - Category: Cardiology Authors: Source Type: research
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