Spatiotemporal analysis of spontaneous myogenic contractions in the urinary bladder of the rabbit; timing and patterns reflect reported electrophysiology.

Spatiotemporal analysis of spontaneous myogenic contractions in the urinary bladder of the rabbit; timing and patterns reflect reported electrophysiology.
Am J Physiol Renal Physiol. 2017 May 24;:ajprenal.00156.2017
Authors: Hulls CM, Lentle RG, King QM, Reynolds GW, Chambers JP
Abstract
The dynamics of propagating myogenic contractions in the wall of the resting ex vivo urinary bladder of the rabbit were characterised by spatiotemporal maps and related to cyclic variation in intravesical pressure (pves). Patches of propagating contractions (PPCs) enlarged and involuted in near synchrony with peaks in intravesical pressure (pves) (3.85 mean ± 0.3cpm). and were preceded by regions of stretch. The maximum area of the bladder undergoing contraction (55.28±2.65 %) and the sizes of individual PPCs (42.61 ± 1.65 mm2) coincided with the peak in pves. PPCs, originated and propagated within temporary patch domains (TPDs) and comprised groups of near synchronous cyclic propagating individual contractions (PICs). The TPDs were located principally along the vertical axis of the anterior surface of the bladder. The sites of origin of PICs within PPCs were inconsistent, consecutive contractions often propagating in opposite directions along linear maps of strain rate. Similar patterns of movement occurred in areas of the anterior bladder wall that had been stripped of mucosa. Intravesical pressure (pves) varied cyclically with area of contracti...

Source: Am J Physiol Renal P... - May 24, 2017 Category: Urology & Nephrology Authors: Hulls CM, Lentle RG, King QM, Reynolds GW, Chambers JP Tags: Am J Physiol Renal Physiol Source Type: research