Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPAR{alpha}

In conclusion, diabetes-induced overexpression of miR-21 in the retina is at least partly responsible for PPARα downregulation in DR. Targeting miR-21 may represent a novel therapeutic strategy for DR.

Source: Diabetes - May 22, 2017 Category: Endocrinology Authors: Chen, Q.; Qiu, F.; Zhou, K.; Matlock, H. G.; Takahashi, Y.; Rajala, R. V. S.; Yang, Y.; Moran, E.; Ma, J.-x. Tags: Complications Source Type: research