Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema

Conclusions
RA regulates lung microvascular angiogenesis; the endothelium produces CYP26A1 which is increased in emphysema, possibly leading to reduced RA availability. These data highlight a role for RA in maintenance of the human pulmonary microvascular endothelium.

Source: Thorax - May 15, 2017 Category: Respiratory Medicine Authors: Ng-Blichfeldt, J.-P., Alcada, J., Montero, M. A., Dean, C. H., Griesenbach, U., Griffiths, M. J., Hind, M. Tags: Chronic obstructive pulmonary disease Source Type: research