Three new compounds from the roots of Juglans mandshurica Maxim.

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Jing Li, Ping-Sheng Xu, Zhen-Xing Zou, Hui Zou, Hong-Ping Long, Lei-Hong Tan, Rui-Huan Liu, Yi-Kun Wang, Kang-Ping Xu, Gui-Shan Tan A new biflavone glycoside juglbiflavone A (1) along with two new lupane-type triterpenes (2-3) were identified from the roots of Juglans mandshurica Maxim. Their structures and absolute configurations were elucidated by extensive spectroscopic methods including 1D/2D NMR, HRESIMS and CD. Compound 1 is the first example of biflavone glycoside consisted of a flavanol unit and a flavone unit from this genus, which also exhibited moderate cytotoxic activity against SGC-7901 and A549 cell lines in vitro with IC50 values of 10.08±0.52μM and 12.44±1.21μM, respectively. Graphical abstract

Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research