Can/should you add Tmz to short course RT for GBM in the elderly? Yes.

In elderly patients with glioblastoma, the addition of temozolomide to short-course radiotherapy resulted in longer survival than short-course radiotherapy alone. An interesting discussion: not adding Tmz for uMGMT older patients based on this data (a point they seem intentionally not to make in the abstract). I'm not sure what the reticence is to make Tmz treatment recommendations based on MGMT status. Just the general... Can/should you add Tmz to short course RT for GBM in the elderly? Yes.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums