TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renb ök mold.

TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold. Dermatol Online J. 2017 Mar 15;23(3): Authors: Craddock LN, Cooley M, Endo JO, Longley BJ, Caldera F Abstract TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Although there are no treatment consensusguidelines, management options include stoppingtherapy, switching to a different TNF-α inhibitor orustekinumab (in severe cases), or continuing TNF-αinhibitor therapy with addition of topical, intralesional,or systemic immunosuppressants. PMID: 28329519 [PubMed - in process]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research