HIV-1 Integrase Inhibitors Resistance: Update of the Current Literature

Opinion statementIntegrase strand transfer inhibitors (INSTIs) have become the most important class of anti-HIV-1 drugs used as third element of the classic three-agent regimen. In addition, they have become pillars of simplified therapeutic schemes. They represent a fundamental resource which cannot be misused. In particular, the most worrisome risk is the occurrence of class resistance that could prevent physicians from employing this impressive weapon in the anti-HIV-1 armamentarium. A precise insight into mechanisms and pathway of resistance is necessary to use these drugs wisely. Pending the advent of new-generation INSTIs, differences among the ones currently available must be kept in mind, especially the greater barrier to resistance displayed by dolutegravir when compared with raltegravir and elvitegravir.
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research