Ageing is not associated with an altered immune response during Trypanosoma cruzi infection: Ageing and Trypanosoma cruzi infection.

Ageing is not associated with an altered immune response during Trypanosoma cruzi infection: Ageing and Trypanosoma cruzi infection.
Exp Gerontol. 2017 Jan 25;:
Authors: Colato RP, Brazão V, Santello FH, Toldo MP, do Vale GT, Tirapelli CR, Pereira-da-Silva G, do Prado JC
Abstract
The aims of this work were to evaluate the influence of ageing on the magnitude of the immune response in male Wistar rats infected with the Y strain of Trypanosoma cruzi (T. cruzi). Infected young animals displayed enhanced CD4(+) T cells as compared to uninfected counterparts. Ageing also triggered a significant reduction in CD8(+) T cells compared to young and uninfected groups. The percentage of spleen NKT cells was reduced for all groups, regardless of the infection status. Significant decreased B-cells was noted in aged controls and infected animals as compared to young counterparts. A significant decrease in MHC class II (RT1B) expression in all aged animals was observed, whether infected or not. The highest and significant levels of Thiobarbituric Acid Reactive Substances (TBARS) were noted in the aged and infected animals as compared to young-infected ones (16day). Consequently superoxide dismutase (SOD) activity was reduced for both control and infected aged animals. Significant elevation of 8-isoprostane levels was found in aged control and infected animals. Plasma glutathione (GSH) concentration was reduced in aged control animals, as well as, i...

Source: Experimental Gerontology - January 24, 2017 Category: Geriatrics Authors: Colato RP, Brazão V, Santello FH, Toldo MP, do Vale GT, Tirapelli CR, Pereira-da-Silva G, do Prado JC Tags: Exp Gerontol Source Type: research