Gene regulation by structured mRNA elements.

Gene regulation by structured mRNA elements.
Trends Genet. 2014 Apr 26;
Authors: Wachter A
Abstract
The precise temporal and spatial coordination of gene activity, based on the integration of internal and external signals, is crucial for the accurate functioning of all biological processes. Although the basic principles of gene expression were established some 60 years ago, recent research has revealed a surprising complexity in the control of gene activity. Many of these gene regulatory mechanisms occur at the level of the mRNA, including sophisticated gene control tasks mediated by structured mRNA elements. We now know that mRNA folds can serve as highly specific receptors for various types of molecules, as exemplified by metabolite-binding riboswitches, and interfere with pro- and eukaryotic gene expression at the level of transcription, translation, and RNA processing. Gene regulation by structured mRNA elements comprises versatile strategies including self-cleaving ribozymes, RNA-folding-mediated occlusion or presentation of cis-regulatory sequences, and sequestration of trans-acting factors including other RNAs and proteins.
PMID: 24780087 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - April 26, 2014 Category: Genetics & Stem Cells Authors: Wachter A Tags: Trends Genet Source Type: research