Direct assembly of multiply oxygenated carbon chains by decarbonylative radical –radical coupling reactions

Direct assembly of multiply oxygenated carbon chains by decarbonylative radical –radical coupling reactionsKengo Masuda, Masanori Nagatomo& Masayuki InoueNature Chemistry 8, 1105 –1111 (2016)doi:10.1038/nchem.2636Pentoses and hexoses represent important structural motifs in bioactive secondary metabolites, though their synthesis often requires several elongation steps. Now, a method for radical –radical coupling reactions of sugar derivatives enables the single-step preparation of the oxygenated carbon chains of several natural products, including sagittamide D, maitotoxin and hikizimycin.

Source: Organometallic Current - December 7, 2016 Category: Chemistry Tags: Radical Reactions Source Type: blogs