F – Nucleophilic-Addition-Induced Allylic Alkylation - Journal of the American Chemical Society (ACS Publications)

F – Nucleophilic-Addition-Induced Allylic Alkylation - Journal of the American Chemical Society (ACS Publications)Herein we present a novel strategy based on palladium-catalyzed allylic alkylation by taking advantage of the nucleophilic addition of external fluoride ontogem-difluoroalkenes as the initiation step. The merit of this protocol is highly appealing, as it enables a formal allylation of trifluoroethylarene derivatives through the in situ generation of β-trifluorocarbanions, which otherwise are deemed to be problematic in deprotonative allylation. 

Source: Organometallic Current - December 6, 2016 Category: Chemistry Tags: Alkylation Allylic Fluorination Pd Catalyzed Source Type: blogs