Olodaterol/tiotropium cost effective for COPD in UK
The 2019 GOLD Guidelines make a new distinction in how to choose initial and subsequent COPD treatment. Do you know what that is? Answer and 4 more questions, here.
Consequences of a late COPD diagnosis, a blood test to stratify mortality risk, and 6 other new studies offer insights into improving care for COPD patients.
CONCLUSION: Chronic disease incidence estimates based on CCDSS data are decreasing over time, but not at a constant rate. Further investigations are needed to assess if this decrease is associated with changes in health status, data quality, or physician practices. As well, population characteristics that may influence changing incidence trends also require exploration. PMID: 31210047 [PubMed - in process]
Publication date: Available online 18 June 2019Source: Journal of Ginseng ResearchAuthor(s): Anna Rita Bilia, Maria Camilla BergonziAbstractGinseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product which is essential for the evaluation of effectiveness and safety....
Conclusions In obese patients, complete airway closure is frequent during anesthesia and is worsened by Trendelenburg pneumoperitoneum, which increases airway opening pressure and alveolar pressure: besides preventing alveolar derecruitment, this yields misinterpretation of respiratory mechanics and generates a pressure threshold to inflate the lung that can reach high values, spreading concerns on the safety of pressure-controlled modes in this setting.
In this report, we propose a tool for the meta-analysis of family-based rare variant associations, metaFARVAT. metaFARVAT is based on a quasi-likelihood score for each variant. These scores are combined to generate burden test, variable-threshold test, sequence kernel association test (SKAT), and optimal SKAT statistics. The proposed method tests homogeneous and heterogeneous effects of variants among different studies and can be applied to both quantitative and dichotomous phenotypes. Simulation results demonstrated the robustness and efficiency of the proposed method in different scenarios. By applying metaFARVAT to data...
Conclusions: WBV training can be effective for improving balance and gait speed in the elderly. The intervention is also effective in improving walking performance following stroke and in patients with knee osteoarthrosis. However, no effect was found on gait quality in the elderly or on balance in stroke and multiple sclerosis patients. The results are too heterogenous in COPD to conclude on the effect of the treatment.
Encouraging fitness in middle age could help delay development, progression, and death from COPD Related items fromOnMedica Childhood fitness leads to healthy lungs as adult Athletes should be pre-screened for heart defects Doctors urged to prescribe more exercise Regular not excessive exercise link to better mental health Body size may have bigger impact on lifespan in women
Condition: Respiratory Failure With Hypercapnia Intervention: Procedure: HFNCOT+ECCO2R Sponsors: Policlinico Hospital; Niguarda Hospital; San Gerardo Hospital; Ospedale San Paolo Recruiting
Condition: Chronic Obstructive Pulmonary Disease Intervention: Drug: Quercetin Sponsors: Temple University; National Institutes of Health (NIH); Quercegen Pharmaceuticals; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting