Int érêt pronostique de l’infiltration du chorion dans les tumeurs vésicales pT1

Conclusion Le classement des ces tumeurs en fonction de l’importance d’envahissement du chorion et de l’infiltration de la musculaire muqueuse a prouvé son efficacité à travers les taux de récidive et de progression tumorale chez nos malades. Introduction The aim of our study was to evaluate the prognostic impact of tumor infiltration depth of the lamina propria and invasion or non-invasion of the muscularis mucosa of pT1 bladder tumors, studying recurrence and progression rate, overall survival, disease-free survival and progression-free survival. Patients and methods All slides were reviewed to determine the presence or absence of muscularis mucosa, invasion above (pT1a) or below (pT1b) the muscularis mucosa, and the invasion depth of the lamina propria (pT1m: a single focus of lamina propria invasion ≤0.5mm, pT1e: single focus >0.5mm of lamina propria invasion or multiple micro-invasive area). Results Depending on the invasion of the muscularis mucosa, the rate of recurrence and progression was more frequent in pT1b tumors in comparison to patients classified pT1a, with a recurrence rate of 84.6% (p =0.0012) and a progression rate of 38.5% (p =0.003). Depending on the degree of invasion of the lamina propria, the rate of recurrence and progression was more frequent for pT1e tumors in comparison to pT1m, with a recurrence rate of 57.2% (p =0.05) and a progression rate of 17.9% (p =0.11). Disease-free survival was 70.3 months for pT1a tumors against 53....
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research