SAMHD1 polymorphisms were significantly correlated with HIV/SIV virus load in PBMC from Chinese rhesus macaques and cynomolgus macaques.

Conclusion-Based on these results, we concluded that SAMHD1 polymorphisms did not affect SIVmac239 replication in CM, but perhaps altered HIV-2ROD infection; however, different sites of the SAM domain of SAMHD1 were responsible for restricting the replication of different viruses in CR. PMID: 27758709 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/27758709?dopt=Abstract

Source: Current HIV Research - October 17, 2016 Category: Infectious Diseases Authors: Ling F, He DD, Wang W, Jin YB, Zhang HL Tags: Curr HIV Res Source Type: research

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