Cytotoxic 9,19-cycloartane triterpenoids from the roots of Cimicifuga foetida L.

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Guo-Lei Zhu, Yin Nian, Di-Fan Zhu, Luo-Sheng Wan, Ni-Man Bao, Wei-Hua Wang, Lin Zhou, Ming-Hua Qiu Eight new cycloartane triterpenoids (1–8), along with eight known analogues (9–16), were isolated from the roots of Cimicifuga foetida L. Their structures were elucidated by spectroscopic analysis and acidic hydrolysis. All of the new compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compound 2 showed inhibitory activities with IC50 values raging from 2.61 to 3.32μM. Graphical abstract

Source: Phytochemistry Letters - September 29, 2016 Category: Chemistry Source Type: research