Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction –induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice

Surgical interventions such as tooth extraction increase the chances of developing osteonecrosis of the jaw in patients receiving bisphosphonates (BPs) for the treatment of bone-related diseases. Tooth extraction is often performed to eliminate preexisting pathological inflammatory conditions that make the tooth unsalvageable; however, the role of such conditions on bisphosphonate-related osteonecrosis of the jaw (BRONJ) development after tooth extraction is not clearly defined. Here, we examined the effects of periapical periodontitis on tooth extraction –induced BRONJ development in mice.

Source: Journal of Endodontics - September 12, 2016 Category: Dentistry Authors: Minju Song, Abdullah Alshaikh, Terresa Kim, Sol Kim, Michelle Dang, Shebli Mehrazarin, Ki-Hyuk Shin, Mo Kang, No-Hee Park, Reuben H. Kim Tags: Basic Research Source Type: research