The communicative impairment as a core feature of schizophrenia: Frequency of pragmatic deficit, cognitive substrates, and relation with quality of life
Impairments in specific aspects of pragmatic competence, supporting the use of language in context, are largely documented in schizophrenia and might represent an indicator of poor outcome. Yet pragmatics is rarely included in clinical settings. This paper aims to promote a clinical consideration of pragmatics as a target of assessment and intervention. We investigated the frequency of the pragmatic deficit, its cognitive substrates, and the relation with quality of life.
Publication date: Available online 8 October 2020Source: Journal of Pharmacological SciencesAuthor(s): Yoshifumi Inoue, Kimiko Tsuchimori, Hiroshi Nakamura
Publication date: Available online 9 October 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Miquel Bioque, Alexandre González-Rodríguez, Clemente Garcia-Rizo, Jesús Cobo, José Antonio Monreal, Judith Usall, Virginia Soria, PNECAT Group, Javier Labad
Publication date: March 2021Source: Schizophrenia Research: Cognition, Volume 23Author(s): Carole Leung, Ka-Shun Lei, Shu-Mei Wang, Bess Yin-Hung Lam
Publication date: March 2021Source: Schizophrenia Research: Cognition, Volume 23Author(s): Hiroki Okada, Daisuke Hirano, Takamichi Taniguchi
Alkermes hopes to introduce a new treatment for schizophrenia and bipolar disorder that minimizes weight gain.
Conclusion: Marked differences between Tunisia and Germany exist in public beliefs about the causes of mental disorders and their treatment, which correspond to differences in cultural orientations prevailing in these countries. Mental health professionals need to be sensitive to the particular cultural context in which they operate, in order to be able to reach those they intend to care for. PMID: 33029184 [PubMed]
Cochrane Corner Summary of Review Titled: "Peer Support for People with Schizophrenia or Other Serious Mental Illness". Issues Ment Health Nurs. 2020 Oct 07;:1-3 Authors: Ewens B, Barnard-Towell A, Mortimer-Jones S, Kemp V, Cole A PMID: 33027603 [PubMed - as supplied by publisher]
Contributors : Haihong Ye ; Jialu ZhaoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusDifferential translation significantly contributes to gene expression regulation and FMRP is one of the upstream translation regulators in the PFC of MK-801-exposed juvenile male miceAcute exposure to the NMDA receptor antagonist MK-801 induces schizophrenia-like behavioral endophenotypes in juvenile male mice. However, the genome-wide gene expression changes that occur at the translation level in the brains of this model are unclear. Here, we performed ribosome profiling analysis on the pref...
People with serious mental illness (SMI), including schizophrenia, bipolar disorder, and major depressive disorder, have a higher mortality rate and shortened life expectancy. This is mainly attributable to physical diseases, particularly cardiovascular diseases (CVDs). Important risk factors for CVDs are obesity and other metabolic abnormalities, which are especially prevalent in people with SMI. Several factors contribute to this increased risk, including unhealthy lifestyles. Psychotropic medication independently further increases this risk. In this review we want to examine the relationship between obesity and other co...
Translational Psychiatry, Published online: 09 October 2020; doi:10.1038/s41398-020-01026-7Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4