Diversities of Calreticulin Gene Mutations in Macedonian Patients With Essential Thrombocythemia.

CONCLUSION: Our results showed that a wide range of different CALR mutations are associated with a distinct ET clinical phenotype that is associated with the male gender, younger age at diagnosis, higher platelet and lower leukocyte and erythrocyte counts and lower hemoglobin level, and a milder clinical course. The relatively high frequency of new insertion/deletion mutations indicate that the use of fluorescent polymerase chain reaction followed by capillary electrophoresis is the method of choice for the analysis of these defects.
PMID: 27521277 [PubMed - in process]

Source: Clinical Lymphoma and Myeloma - July 31, 2016 Category: Cancer & Oncology Authors: Panovska-Stavridis I, Eftimov A, Ivanovski M, Stojanovic A, Georgievski B, Cevreska L, Dimovski AJ Tags: Clin Lymphoma Myeloma Leuk Source Type: research