Diagnostic Guidelines for Fetal Alcohol Syndrome Updated Diagnostic Guidelines for Fetal Alcohol Syndrome Updated
Proposed updates to diagnostic guidelines for fetal alcohol spectrum disorders reflect advancements in understanding of the cognitive, behavioral, and physical distinctions of these disorders.Medscape Medical News
From the latestNIAAA Director's Blog:Fetal alcohol spectrum disorders, also known as FASD, is a term that refers to the broad range of lifelong birth defects and neurodevelopmental abnormalities that occur as a result of prenatal alcohol exposure. In this edition of my blog, I want to remind everyone that there is no known safe level of alcohol, or time to drink, during pregnancy. Read more...
ConclusionsThe findings highlight an attitude-behavior gap and suggest that positive preventive attitudes are insufficient to elicit FASD preventive behavior. Interventions are needed that go beyond education to build intrinsic motivation and structural support to refrain from alcohol use during pregnancy.
This study confirms that moderate levels of ethanol exposure to developing embryos have subtle effects on spatial working memory in adulthood. Our data thus suggest that zebrafish may be a promising model system for studying the effects of alcohol on learning and decision-making, but also for developing treatments and interventions to reduce the negative effects of prenatal alcohol.
CONCLUSION: By now interventions against fetal alcohol spectrum disorder targeting oxidative stress includes astaxanthin, Ascorbic acid (Vitamin C), Vitamin E, beta-carotene, (-)-Epigallocatechin-3-gallate (EGCG), Omega-3 fatty acids, etc (see Fig.1). However, most interventions are only assayed in animal models, more clinical trials are needed to show whether antioxidants make an effort against FASD damage. PMID: 30205148 [PubMed - as supplied by publisher]
Alcohol is now recognized as the leading preventable cause of birth defects and developmental disorders in the United States. Each year thousands of children are born with life-long disabilities because they were exposed to alcohol prenatally. On September 9th, the National Institute on Alcohol Abuse and Alcoholism recognizes International Fetal Alcohol Spectrum Disorders (FASD) Awareness Day as a reminder that there is no “safe” level of drinking while pregnant.
On Thursday, September 27, 2018 at 1:00 p.m. Eastern, NIAAA will co-host a Twitter chat with the National Organization on Fetal Alcohol Syndrome (NOFAS). For more information, follow@NIAAAnews on Twitter.
Prenatal ethanol exposure (PE) leads to a variety of physical, cognitive, and behavioral deficits, collectively referred to as fetal alcohol spectrum disorders (FASD). One of the deficits is increased risk of addiction to drugs of abuse (Alati et al., 2006; Barbier et al., 2009). Indeed, our previous work shows that PE leads to enhanced amphetamine conditioned place preference and self-administration in adult rats reared in the standard laboratory environment (Hausknecht et al., 2015; Hausknecht et al., 2017; Wang et al., under review).
CONCLUSIONS: These data demonstrate that a partial or complete knockdown of Mns1 interacts with PAE to increases susceptibility to ocular defects and correlating craniofacial and brain anomalies, likely though interaction of alcohol with motile cilia function. These results further our understanding of genetic risk factors that may underlie susceptibility to teratogenic exposures. This article is protected by copyright. All rights reserved. PMID: 30129265 [PubMed - as supplied by publisher]
Originally described in 1923 by Pierre Robin, Pierre Robin sequence (PRS) is a condition characterized by a triad consisting of micrognathia, glossoptosis and breathing problems due to obstruction of the upper airway . The prevalence of PRS is highly variable and reported to be between 1 in 2000 to 1 in 30,000 . PRS can be found as isolated disease or in association with other syndromes such as Stickler sundrome, Fetal Alcohol Syndrome and Monosomy 22q11 or DiGeorge Syndrome . Although the strong concurrence of Obstructive Sleep Apnea and PRS has been known, no previous study has reported other sleep problems and ...
We report that exposure to 1% alcohol from either 6 to 24, or 24 to 26 hours postfertilization reduces the social behavior of adult casper zebrafish. Our findings set the stage for the use of this important zebrafish resource in studies of FASD. PMID: 30107225 [PubMed - as supplied by publisher]