Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL ‐31 neutralizing antibody

ConclusionThese results demonstrate that an IL‐31 mAb can inhibit IL‐31‐mediated pruritus in vivo, and could be an effective therapy for pruritic skin conditions like AD where IL‐31 upregulation may play a role.

Source: Journal of the European Academy of Dermatology and Venereology - August 7, 2016 Category: Dermatology Authors: K.E. Lewis, M.S. Holdren, M.F. Maurer, S. Underwood, B. Meengs, S.H. Julien, K.A. Byrnes ‐Blake, J.A. Freeman, T.R. Bukowski, A.C. Wolf, N.B. Hamacher, M.W. Rixon, S.R. Dillon Tags: Original Article Source Type: research