Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells.

Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells. Adv Pharmacol. 2016;77:281-306 Authors: Goligorsky MS, Hirschi K Abstract This brief overview of premature senescence of dysfunctional endothelial and endothelial progenitor cells provides information on endothelial cell differentiation and specialization, their ontogeny, and controversies related to endothelial stem and progenitor cells. Stressors responsible for the dysfunction of endothelial and endothelial progenitor cells, as well as cellular mechanisms and consequences of endothelial cell dysfunction are presented. Metabolic signatures of dysfunctional endothelial cells and senescence pathways are described. Emerging strategies to rejuvenate endothelial and endothelial progenitor cells conclude the review. PMID: 27451101 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research