Posttranslational Arginylation Regulates Striated Muscle Function

In this article, we propose the hypothesis that the posttranslational arginylation of proteins, a process catalyzed by the enzyme arginyl-tRNA-transferase, regulates active and passive force generation in striated muscles. Specifically, we propose that proteins essential for muscle contraction and force production are regulated by arginylation, including myosin heavy chain, troponin, actin, and titin filaments.

Source: Exercise and Sport Sciences Reviews - June 17, 2016 Category: Sports Medicine Tags: Articles Source Type: research