Small Lymphocytic Lymphoma Presenting As a Paraneoplastic Syndrome With Acute Central Nervous System Demyelination.

Small Lymphocytic Lymphoma Presenting As a Paraneoplastic Syndrome With Acute Central Nervous System Demyelination. Clin Lymphoma Myeloma Leuk. 2014 Feb 18; Authors: Devito N, Mui K, Jassam Y, Taylor L, Pilichowska M, Cossor F PMID: 24630921 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Clin Lymphoma Myeloma Leuk Source Type: research

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In this study we sought to identify mechanisms of disease development by comparing the immune tumor microenvironment (iTME) of patients with POEMS syndrome to that of patients with MGUS.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
POEMS syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The combination of a proteasome inhibitor, an IMiD and corticosteroid is known to be highly effective among patients with myeloma.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
ConclusionThis retrospective analysis provides important information on the clinical characteristics of POEMS syndrome in Indian patients, which will help the clinician’s decision-making process.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
This study is aimed at bringing together various evidences from the field of immunological and hematological research, at exposing contradictions, and at revealing novel insights on the association between ANCA-associated vasculitis and hematologic malignancies. PMID: 31198793 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
ConclusionThe data presented here would be key to the clinician’s decision-making process particularly in the Indian context.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
We report a retrospective analysis of 49 cases from a single tertiary-care center in New Delhi, India, including 10 patients who underwent hematopoietic stem-cell transplantation. Clinical features, responses, and outcomes were similar to the Western and Eastern literature, though with some unique features.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Clin Exp Dermatol Source Type: research
Paraneoplastic cerebellar degeneration (PCD) is characterized by a subacute progression from gait ataxia to diplopia, nystagmus, dysarthria, and dysphagia. Blurry vision, oscillopsia, and transient opsoclonus may also be seen [1]. This constellation of symptoms typically occurs early in the disease course and precedes the clinical manifestation of the primary malignancy in more than half of cases [2]. The most common malignancies associated with PCD include gynecologic and breast cancer, small cell lung cancer, and Hodgkin's lymphoma.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Conclusions:Inflammatory neuropathies especially Lymphoma followed by Sjogrens syndrome was the most common diagnosis in patients with cranial neuropathy and peripheral nerve disorders. The peripheral nerve disorder localised to the root level in a majority of the patients in our cohort. This is likely secondary to blood–nerve barrier being most vulnerable at this level.Disclosure: Dr. Rodrigues has nothing to disclose. Dr. Dyck has nothing to disclose. Dr. Kao has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neuromuscular and Clinial Neurophysiology (EMG): Peripheral Neuropathy II Source Type: research
Abstract Multiple myeloma is a clonal hematopoietic neoplasm characterized by the proliferation of malignant plasma cells and associated end-organ damage, most notably lytic lesions in the bones. Osteosclerotic myeloma is an unusual variant of the disease in which the skeletal involvement is characterized by sclerotic lesions instead of classical lytic lesions. The disease can be associated with paraneoplastic symptoms, which have been given the acronym POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes). In addition to clonal plasma cell dyscrasias, some cases of POEMS syndrome ...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
More News: Cancer & Oncology | Lymphoma | Myeloma | Paraneoplastic Syndrome