Progress in the Treatment of Primary Plasma Cell Leukemia EDITORIALS

Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: EDITORIALS Source Type: research

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Acute graft-versus-host disease (GVHD) can affect the central nervous system (CNS). The role of microglia in CNS-GVHD remains undefined. In agreement with microglia activation, we found that profound morphological changes and MHC-II and CD80 upregulation occurred upon GVHD induction. RNA sequencing–based analysis of purified microglia obtained from mice with CNS-GVHD revealed TNF upregulation. Selective TNF gene deletion in microglia of Cx3cr1creER Tnffl/– mice reduced MHC-II expression and decreased CNS T cell infiltrates and VCAM-1+ endothelial cells. GVHD increased microglia TGF-β–activated kinase...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Condition:   Acute Myeloid Leukemia Intervention:   Drug: HMPL-306 Sponsor:   Hutchison Medipharma Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Leukemia, Myeloid;   Leukemia, Myeloid, Acute Intervention:   Biological: CD123 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma;   Leukemia, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma, Large B-Cell, Diffuse;   Leukemia, B-cell;   Lymphoma, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Leukemia, Myeloid;   Leukemia, Myeloid, Acute Intervention:   Biological: CD123 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma;   Leukemia, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma, Large B-Cell, Diffuse;   Leukemia, B-cell;   Lymphoma, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Acute Myeloid Leukemia Intervention:   Drug: HMPL-306 Sponsor:   Hutchison Medipharma Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cancer & Oncology | Leukemia